동종 탈회골의 크기가 유도골 형성에 미치는 영향에 관한 실험적 연구
Experimental study of effect on induced osteogenesis according to the size of demineralized allogeneic bone
방만혁, 김성숙, 최기룡, 민승기,
소속 상세정보
방만혁 ( ) - 원광대학교
김성숙 ( ) - 원광대학교
최기룡 ( ) - 원광대학교
민승기 ( ) - 원광대학교
KMID : 0360119950170040350
Abstract
As early as 1889, treatment of ostemyelitis was reported using xenogeneic demineralized bone. In 1995, Urist discovered that demineralized long bone fragment, even when implanted in nonskeletal tissue, would stimulate osteogenesis. The clinical
use
of
demineralized bone of Oral and Maxillofacial surgery is not new.
The demineralized bone implants were used for 1) interposition within osteotomy gaps, cystic defects, alveolar clefts ; 2) augmentation, over intact bone surfaces ; 3) construction of new bone within soft tissue.
Demineralized bone grafts invokes a induced osteogenesis which is the transformation of host cells into osteoblasts.
Demineralized bone has identified several factors that modulate the osteogeneic response : sterilization method, recipient age, particle size etc. Especially, pulverization of bone matrix may enhance its osteoinductive properties, to allow rapid,
efficient bridging of large defects.
the purpose of the present report was to describe the potential efficacy of demineralized allogeneic bone powder of skull of rabbits as a particle size ; 212 ㎛, 710㎛, 1 mm each other.
Microscopic finding in our experimental studies shown that 710 ㎛ demineralized bone powder is the most potent osteogenic response, and then 212㎛, 1 mm size. Densitometric analysis shown that density of all group was continue to increase untill
4
weeks
after operation, and then continue to decrease.
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